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Pharmacokinetic interaction with potent inhibitors of CYP3A4 (increased plasma alfuzosin concentrations).

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An American study of 2115 randomly selected community men with no previous prostate surgery or malignancy was conducted to evaluate the impact of urinary symptoms on health-related QOL, including degree of bother (based on AUA bother score).

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Experimental works in lumbar-to-sacral nerve rerouting and in regenerative medicine including use of stem cells to mitigate or reverse spinal cord damage producing neurogenic bladder dysfunction are still in their infancy, and more research will be needed to see if the promising results of some small pilot studies are confirmed in larger, controlled studies with long-term followup.

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The appearance of PIN warrants increased surveillance of the prostate for development of an invasive carcinoma because the presence of PIN that is high grade suggests an increased risk for subsequent appearance of adenocarcinoma.

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If you are also using ketoconazole (Nizoral), itraconazole (Sporanox), or ritonavir (Norvir).

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The risk of surgical therapy was not affected by doxazosin, whereas it was reduced significantly by finasteride and accordingly by combination medical therapy.

Over time, the relapse rate is high, exceeding 50%.

Studies with other pharmacologic agents used for the management of BPH symptoms have also supported the importance of the bother score as a measure of QOL.

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The duration of catheter placement is an area of debate but typically is 1 to 7 days, depending upon patient comorbidities (ie, diabetes mellitus, ambulatory impairment, prostatic enlargement, and expectation of resolution of initial need for catheterization).

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